Technology
Key to the success of Photodiversity is the joint technical expertise of Booker-Milburn and Cox which amounts to over 50 years combined experience in photochemistry, organic synthesis, medicinal chemistry and drug design. We have a number of commercial and custom items of technology which in total enable us to offer a unique service to our clients.
• Various batch photochemical reactors (125 - 600W) for scales of mg's to g's per day
• Unique, in-house customised high-capacity flow photochemical reactors (1.5 - 5 kW) for scales of 100 g's to kg's per day
• Various light sources covering key parts of UV spectrum for organic photochemistry (250-400 nm)
• Longer wavelength sources (> 400 nm to Vis)
• Tecan
liquid
handling system for reaction preparation, analysis, work-up
and
final sample preparation
• Biotage
microwave
and Thales H-Cube flow reaction platforms
• Well-plate equipped HPLC-MS for library analysis.
MS and UV directed automated HPLC purification for final product
purification
• Genevac
systems for
dry
down of multiple samples
• Biotage
and
ISCO flash systems
for fragment and building block
purification
• ICM-Chemist
software employed for fragment and diversity library design
and building block selection
• Commercially-derived
and bespoke synthon
collections